Alert SA-AGAM-07 (Coeae1f/Coeae2f)#
This alert reports selection signals on Chromosome 2RL within the region 89,888,868-90,271,142 bp.
Selection signals#
Selection signals overlapping this genome region are shown in the figure below.
Cohorts affected#
Overlapping selection signals are found in the following cohorts.
| Cohort | Country | Region | District | Taxon | Year | Quarter | Sample Size |
|---|---|---|---|---|---|---|---|
| Burkina Faso / Houet / gambiae / 2012 / Q3 | Burkina Faso | Hauts-Bassins | Houet | gambiae | 2012 | 3 | 73 |
| Burkina Faso / Houet / gambiae / 2014 / Q3 | Burkina Faso | Hauts-Bassins | Houet | gambiae | 2014 | 3 | 41 |
| Benin / Djougou / gambiae / 2017 / Q2 | Benin | Donga | Djougou | gambiae | 2017 | 2 | 30 |
| Benin / Djougou / gambiae / 2017 / Q3 | Benin | Donga | Djougou | gambiae | 2017 | 3 | 34 |
| Cote d'Ivoire / Sud-Comoe / gambiae / 2017 / Q3 | Cote d'Ivoire | Comoe | Sud-Comoe | gambiae | 2017 | 3 | 37 |
| Ghana / La-Nkwantanang-Madina / gambiae / 2017 / Q4 | Ghana | Greater Accra Region | La-Nkwantanang-Madina | gambiae | 2017 | 4 | 200 |
| Ghana / Adansi South / gambiae / 2018 / Q4 | Ghana | Ashanti Region | Adansi South | gambiae | 2018 | 4 | 29 |
| Ghana / Bekwai Municipal / coluzzii / 2018 / Q4 | Ghana | Ashanti Region | Bekwai Municipal | coluzzii | 2018 | 4 | 53 |
| Guinea / Kissidougou / gambiae / 2012 / Q4 | Guinea | Faranah | Kissidougou | gambiae | 2012 | 4 | 51 |
| Guinea / Macenta / gambiae / 2012 / Q4 | Guinea | Nzerekore | Macenta | gambiae | 2012 | 4 | 51 |
| Mali / Kati / gambiae / 2014 / Q3 | Mali | Koulikouro | Kati | gambiae | 2014 | 3 | 24 |
| Mali / Yanfolila / gambiae / 2012 / Q4 | Mali | Sikasso | Yanfolila | gambiae | 2012 | 4 | 53 |
| Tanzania / Moshi / arabiensis / 2012 / Q3 | Tanzania | Manyara | Moshi | arabiensis | 2012 | 3 | 39 |
Insecticide resistance genes#
The following genes are found within this genome region and may be driving recent positive selection based on evidence for an association with insecticide resistance. Please note that other genes are also within the affected genome region and may be driving selection.
AGAP006227 (Coeae1f)#
This gene encodes a carboxylesterase enzyme. Genetic variation at this gene is associated with resistance to organophosphate insecticides in Anopheles gambiae and Culex pipiens. See also:
Raymond et al. (1998) An overview of the evolution of overproduced esterases in the mosquito Culex pipiens
Nagi et al. (2024) Parallel Evolution in Mosquito Vectors — A Duplicated Esterase Locus is Associated With Resistance to Pirimiphos-methyl in Anopheles gambiae
AGAP006228 (Coeae2f)#
This gene encodes a carboxylesterase enzyme. Genetic variation at this gene is associated with resistance to organophosphate insecticides in Anopheles gambiae and Culex pipiens. See also:
Raymond et al. (1998) An overview of the evolution of overproduced esterases in the mosquito Culex pipiens
Nagi et al. (2024) Parallel Evolution in Mosquito Vectors — A Duplicated Esterase Locus is Associated With Resistance to Pirimiphos-methyl in Anopheles gambiae