Alert SA-AFUN-04 (Rdl)

Alert SA-AFUN-04 (Rdl)#

This alert reports selection signals on Chromosome 3RL within the region 13,537,662-13,737,363 bp.

Selection signals#

Selection signals overlapping this genome region are shown in the figure below.

Cohorts affected#

Overlapping selection signals are found in the following cohorts.

Table 1. Cohorts with selection signals overlapping this selection alert.
Cohort	Country	Region	District	Taxon	Year	Quarter	Sample Size
Ghana / Adansi Akrofuom / funestus / 2014 / Q1	Ghana	Ashanti Region	Adansi Akrofuom	funestus	2014	1	31
Nigeria / Remo North / funestus / 2015 / Q1	Nigeria	Ogun	Remo North	funestus	2015	1	41

Insecticide resistance genes#

The following genes are found within this genome region and may be driving recent positive selection based on evidence for an association with insecticide resistance. Please note that other genes are also within the affected genome region and may be driving selection.

LOC125769835 (Rdl, AFUN2_014608, AFUN016339)#

This gene encodes a subunit of a GABA-gated chloride channel which is the binding target of cyclodiene insecticides including dieldrin and lindane. Mutations in this gene are associated with dieldrin resistance in multiple insect species, including A296G and A296S in Anopheles gambiae (codon 302 in Drosophila melanogaster). Resistance alleles persist in Anopheles populations in sub-Saharan Africa despite a ban on dieldrin use in the 1980s. See also:

Thomson et al. (1993) Conservation of cyclodiene insecticide resistance-associated mutations in insects
Ffrench-Constant et al. (2000) Cyclodiene insecticide resistance: from molecular to population genetics
Wondji et al. (2011) Identification and distribution of a GABA receptor mutation conferring dieldrin resistance in the malaria vector Anopheles funestus in Africa