SA-1 (Vgsc)#
Cohorts affected#
Overlapping signals of selection are found in the following cohorts.
Candidate genes#
AGAP004707 (Vgsc)
Mutations in this gene cause resistance to pyrethroid insecticides and DDT. The most common of these mutations is L995F, which is found across many insect taxa. In Anopheles gambiae s.l, we observe many distinct variants under selection, for example, L995F, L995S, and a haplotype containing both V402L and I1527T (Clarkson et al., 2021).
This form of resistance was first reported in Anopheles gambiae in 1998 (Martinez-Torres et al., 1998). Mutants at this locus are now found throughout sub-Saharan Africa.
Change log#
07-02-2024 - first version published